TRPM2 is activated by intracellular ADP-ribose (ADPR), hydrogen peroxide, and heat,
whereas reported activation mechanisms for TRPM3 include cell swelling and sphingosine;
TRPM4 and TRPM5 gate upon a rise in intracellular Ca2+ and are further strongly activated by heating.
Gating of TRPM6 and TRPM7 is regulated by intracellular levels of Mg2+ and MgATP.